Departments of Obstetrics and Gynecology, Asahikawa Medical College, Asahikawa, Hokkaido, Japan,Biological Science Laboratories, Kao Corporation, Haga, Tochigi, Japan, andDepartment of Dermatology, Asahikawa Medical College, Asahikawa, Hokkaido, Japan.
Int J Dermatol. 2013 Dec;52(12):1500-5. doi: 10.1111/j.1365-4632.2012.05582.x. Epub 2012 Dec 11.
Although the physiological conditions of vulvar skin in Caucasian populations have been characterized, little is known about these conditions in Japanese women.
Skin of the labia, groin, mons pubis, and inner thigh was examined in 40 healthy Japanese women outwith their menstrual period. Skin moisture, skin pH, ceramide content and inflammatory cytokine proteins of the stratum corneum, and bacterial flora were assessed.
Skin moisture was found to be significantly lower in the labia than at the other three sites examined. No differences were found in skin pH. A significant difference in ceramide content was observed between the groin and inner thigh. The ratio of interleukin-1α (IL-1α) and interleukin-1α receptor antagonist (IL-1Ra) was significantly higher in the labia than in the other sites. Numbers of total bacteria, Staphylococcus epidermis, and Lactobacillus spp. were greater in the labia and mons pubis sites compared with the inner thigh. Prevotella spp. were found only in the labia.
In Japanese women, the skin at the labia is drier and more inflammatory than the skin at the groin, mons pubis, and inner thigh; this cannot be explained by the ceramide content and/or pH of the stratum corneum. Prevotella spp. may perform a key role in the vulvar skin of Japanese women.
尽管已经对高加索人群外阴皮肤的生理状况进行了描述，但对日本女性的这些状况却知之甚少。
在非月经期，对 40 名健康的日本女性的外阴、腹股沟、耻骨联合上区和大腿内侧皮肤进行了检查。评估了角质层的皮肤水分、皮肤 pH 值、神经酰胺含量和炎症细胞因子蛋白以及细菌菌群。
发现外阴皮肤的水分明显低于其他三个检查部位。皮肤 pH 值无差异。腹股沟和大腿内侧的神经酰胺含量存在显著差异。外阴部位的白细胞介素-1α（IL-1α）和白细胞介素-1α 受体拮抗剂（IL-1Ra）的比值明显高于其他部位。外阴和耻骨联合上区的总细菌、表皮葡萄球菌和乳杆菌的数量均高于大腿内侧。仅在外阴部位发现普雷沃氏菌属。
在日本女性中，外阴皮肤比腹股沟、耻骨联合上区和大腿内侧皮肤更干燥且更具炎症性；这不能用角质层的神经酰胺含量和/或 pH 值来解释。普雷沃氏菌属可能在外阴皮肤中发挥关键作用。
