齿状回刺激引发的点燃效应。I. 脑电图和行为事件的特征

Kindling with stimulation of the dentate gyrus. I. Characterization of electrographic and behavioral events.

作者信息

Grace G M, Corcoran M E, Skelton R W

机构信息

Department of Psychology, University of Victoria, B.C., Canada.

出版信息

Brain Res. 1990 Feb 19;509(2):249-56. doi: 10.1016/0006-8993(90)90549-q.

DOI:10.1016/0006-8993(90)90549-q

PMID:2322822

Abstract

Once daily for 60 days, hooded rats received unilateral high-frequency stimulation in the hilus of the dentate gyrus (DG), at an intensity sufficient to evoke epileptiform afterdischarge (AD). Although most rats eventually developed generalized stage-5 seizures (Generalized group), some did not progress beyond partial stage-1 or stage-2 seizures (Partial group). Hilar kindling also displayed several other characteristics that distinguished it from typical limbic kindling, including low rate of development, marked instability of the seizures, and little or no growth in duration of AD.

摘要

每天一次，持续60天，对有头罩的大鼠的齿状回（DG）海马进行单侧高频刺激，刺激强度足以诱发癫痫样后放电（AD）。尽管大多数大鼠最终发展为全身性5期癫痫（全身性组），但有些大鼠并未进展到部分性1期或2期癫痫（部分性组）。海马点燃还表现出其他几个与典型边缘系统点燃不同的特征，包括发展速度低、癫痫发作明显不稳定，以及AD持续时间几乎没有增长或没有增长。