State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
Phytochemistry. 2013 Feb;86:29-35. doi: 10.1016/j.phytochem.2012.11.008. Epub 2012 Dec 7.
Ten sesterterpenoids, leucosceptroids E-N (1-10), possessing an α,β-unsaturated γ-lactone moiety, were isolated from the leaves and flowers of a woody Labiatae, Leucosceptrum canum. Their structures including relative stereochemistry were determined by comprehensive 1D and 2D NMR, MS, and in the case of 1 and 10, by single crystal X-ray diffraction analyses. This class of unique plant terpenoids was designated as leucosceptrane sesterterpenoids (=leucosceptroids). The potent antifeedant activity of the most abundant compound, leucosceptroid G (3), and a representative compound, leucosceptroid N (10), against the generalist plant-feeding insect Helicoverpa armigera suggested that they might also be defense compounds of L. canum against insects.
从木本唇形科植物 Leucosceptrum canum 的叶和花中分离得到了 10 个具有α,β-不饱和γ-内酯部分的倍半萜类化合物， leucosceptroids E-N（1-10）。通过综合的 1D 和 2D NMR、MS 以及单晶 X 射线衍射分析（对于 1 和 10）确定了它们的结构，包括相对立体化学。这一类独特的植物萜类化合物被命名为 leucosceptrane 倍半萜类化合物（= leucosceptroids）。最丰富的化合物 leucosceptroid G（3）和代表性化合物 leucosceptroid N（10）对多食性植物取食昆虫烟青虫具有很强的拒食活性，这表明它们也可能是 L. canum 抵御昆虫的防御化合物。
