Macicková T, Kettner M, Benes L
Ustav experimentálnej farmakológie CFV SAV, Bratislava.
Bratisl Lek Listy. 1990 Jan;91(1):30-7.
Antitrichomonal activity of selected nitrofuran derivatives and asymmetrically substituted ureas was investigated in vitro and in vivo and compared with the activity of the effective therapeutic agent tinidazole. In experimental infection with Trichomonas vaginalis and Tritrichomonas foetus in mice, some substituted urea derivatives exhibited an antiparasitic effect slightly lower than that of tinidazole. The substance N1-(3-nitrophenyl)-N3-(2-pyrimidinyl)urea proved to be the most effective of the substances tested. On the basis of preliminary toxicity tests the chemotherapeutic value of this substance appears to be promising.
研究了所选硝基呋喃衍生物和不对称取代脲的抗滴虫活性，进行了体外和体内试验，并与有效治疗药物替硝唑的活性进行了比较。在小鼠阴道毛滴虫和胎儿三毛滴虫的实验感染中，一些取代脲衍生物表现出略低于替硝唑的抗寄生虫作用。结果证明，N1-(3-硝基苯基)-N3-(2-嘧啶基)脲是所测试物质中最有效的。基于初步毒性试验，该物质的化疗价值似乎很有前景。
