Huang Yafei, Potter Rachel, Sigurdson Wendy, Kasten Tom, Connors Rose, Morris John C, Benzinger Tammie, Mintun Mark, Ashwood Tim, Ferm Mats, Budd Samantha L, Bateman Randall J
Arch Neurol. 2012 Dec;69(12):1591-7. doi: 10.1001/archneurol.2012.18107.
To investigate dynamic changes in human plasma β-amyloid (Aβ) concentrations, evaluate the effects of aging and amyloidosis on these dynamics, and determine their correlation with cerebrospinal fluid (CSF) Aβ concentrations.
A repeated plasma and CSF sampling study.
The Washington University School of Medicine in St Louis, Missouri.
Older adults with amyloid deposition (Amyloid+), age-matched controls without amyloid deposition (Amyloid-), and younger normal controls (YNCs) were enrolled for the study.
Hourly measurements of plasma Aβ were compared between groups by age and amyloidosis. Plasma Aβ and CSF Aβ concentrations were compared for correlation, linear increase, and circadian patterns.
Circadian patterns were observed in plasma Aβ, with diminished amplitudes with aging. Linear increase of Aβ was only observed for CSF Aβ in the YNC and Amyloid- groups, but not in the Amyloid+ group. No linear increase was observed for plasma Aβ. No significant correlations were found between plasma and CSF Aβ concentrations.
Plasma Aβ, like CSF, demonstrates a circadian pattern that is reduced in amplitude with increasing age but is unaffected by amyloid deposition. However, we found no evidence that plasma and CSF Aβ concentrations were related on an hourly or individual basis.
研究人类血浆β-淀粉样蛋白（Aβ）浓度的动态变化，评估衰老和淀粉样变性对这些动态变化的影响，并确定它们与脑脊液（CSF）Aβ浓度的相关性。
一项重复的血浆和脑脊液采样研究。
密苏里州圣路易斯市的华盛顿大学医学院。
纳入有淀粉样蛋白沉积的老年人（淀粉样蛋白阳性）、年龄匹配的无淀粉样蛋白沉积的对照组（淀粉样蛋白阴性）和年轻正常对照组（YNC）进行研究。
按年龄和淀粉样变性对各组间血浆Aβ的每小时测量值进行比较。比较血浆Aβ和脑脊液Aβ浓度的相关性、线性增加和昼夜模式。
在血浆Aβ中观察到昼夜模式，其振幅随衰老而减小。仅在YNC组和淀粉样蛋白阴性组的脑脊液Aβ中观察到Aβ的线性增加，而在淀粉样蛋白阳性组中未观察到。血浆Aβ未观察到线性增加。血浆和脑脊液Aβ浓度之间未发现显著相关性。
与脑脊液一样，血浆Aβ也呈现昼夜模式，其振幅随年龄增长而降低，但不受淀粉样蛋白沉积的影响。然而，我们没有发现证据表明血浆和脑脊液Aβ浓度在每小时或个体水平上相关。
