Department of Ophthalmology, Medical and Health Science Center, University of Debrecen, Nagyerdei krt 98, 4012 Debrecen, Hungary.
Graefes Arch Clin Exp Ophthalmol. 2013 Mar;251(3):917-22. doi: 10.1007/s00417-012-2196-0. Epub 2012 Nov 16.
P-selectin receptor is expressed in platelets and endothelial cells in a cell-activation-dependent manner. Platelet P-selectin (CD62) levels may become elevated in a number of vasoocclusive diseases, including arteriosclerosis, atherothrombosis, and diabetes mellitus (DM). Nonarteritic anterior ischemic optic neuropathy (NAION) is associated with a sudden loss of vision due to the vascular insufficiency of ciliary arteries supplying the optic nerve. In this study, our aim was to investigate the presence of increased platelet reactivity in the development of NAION.
Twenty-one NAION patients, 39 healthy control subjects, and 44 patients suffering from diabetes mellitus (DM) were examined in our case-control, pilot study. Platelet activation was investigated by flow cytometric analysis of the mean fluorescence intensity (MFI) of CD62 on platelets. These results were compared among the different study groups.
NAION patients showed considerably although not significantly (p = 0.2017) higher P-selectin MFI values (71.98 ± 40.30) versus healthy subjects (55.48 ± 20.95), insulin-dependent DM patients (50.02 ± 13.08), and non-insulin-dependent DM subjects (54.72 ± 24.74). However, logistic regression analysis resulted in a statistically significant adjusted effect on the odds of NAION when CD62 MFI values were logarithmically transformed (OR: 3.86, 95 % CI: 1.10 to 13.53, p = 0.0346).
Elevated platelet CD62 positivity may be related to NAION, suggesting a possible role of enlarged platelet activity in the generation of this type of ischemic optic neuropathy.
P-选择素受体在血小板和内皮细胞中以细胞激活依赖的方式表达。血小板 P-选择素（CD62）水平在许多血管闭塞性疾病中可能升高，包括动脉硬化、动脉血栓形成和糖尿病（DM）。非动脉炎性前部缺血性视神经病变（NAION）与由于供应视神经的睫状动脉血管不足导致的视力突然丧失有关。在这项研究中，我们的目的是研究血小板反应性增加在 NAION 发展中的作用。
在我们的病例对照、初步研究中，检查了 21 名 NAION 患者、39 名健康对照者和 44 名糖尿病（DM）患者。通过流式细胞术分析血小板上 CD62 的平均荧光强度（MFI）来研究血小板的激活。将这些结果在不同的研究组之间进行比较。
NAION 患者的 P-选择素 MFI 值（71.98 ± 40.30）明显高于健康对照组（55.48 ± 20.95）、胰岛素依赖型 DM 患者（50.02 ± 13.08）和非胰岛素依赖型 DM 患者（54.72 ± 24.74），但差异无统计学意义（p = 0.2017）。然而，当 CD62 MFI 值对数转换时，逻辑回归分析导致 NAION 的odds 具有统计学显著的调整效应（OR：3.86，95%CI：1.10 至 13.53，p = 0.0346）。
血小板 CD62 阳性率升高可能与 NAION 有关，提示血小板活性增加可能在这种类型的缺血性视神经病变的发生中起作用。
