Unit of General and Emergency Surgery, Department of General, Emergency and Transplant Surgery (GENURTO), University of Palermo, Via Alcide De Gasperi 53, 90146, Palermo, Italy,
Surg Today. 2013 Dec;43(12):1398-405. doi: 10.1007/s00595-012-0442-z. Epub 2012 Dec 11.
Graves' disease can induce alterations of the psychosocial well-being that negatively influence the overall well-being of patients. Among the current treatments, surgery has limited indications, and its impact on the health-related quality of life has not been well clarified. The aim of this study was to assess the impact of surgery on the quality of life.
Fifty-seven patients who underwent total thyroidectomy for Graves' disease in our surgical unit between April 2002 and December 2009 were administered a questionnaire concerning four issues: organic alterations and clinical manifestations, neurovegetative system disturbances, impairment of daily activities, psychosocial problems. Patients were retrospectively questioned after thyroidectomy about the presence of these symptoms in both the pre and postoperative periods.
There was a significant improvement after surgery in all four areas. Organic manifestations and psychosocial problems had higher average improvements, as did some aspects of the neurovegetative system and difficulties in undertaking daily activities. There were no reports of a worsening of symptoms.
Surgery resolved the hyperthyroidism in 100 % of cases, and was associated with a quality of life improvement of about 70 % in the patients. Surgery can therefore provide an immediate and effective resolution of Graves' disease, with benefits in health-related quality of life.
格雷夫斯病可引起社会心理福祉的改变，从而对患者的整体福祉产生负面影响。在目前的治疗方法中，手术的适应证有限，其对健康相关生活质量的影响尚未得到充分阐明。本研究旨在评估手术对生活质量的影响。
2002 年 4 月至 2009 年 12 月期间，我们外科组对 57 例格雷夫斯病患者进行了全甲状腺切除术，他们接受了一份关于四个问题的问卷：器官改变和临床表现、植物神经系统紊乱、日常活动障碍、社会心理问题。在甲状腺切除术后，我们回顾性地询问了这些患者在术前和术后的这些症状。
所有四个领域在手术后都有显著改善。器官表现和社会心理问题的改善程度更高，一些植物神经系统和日常活动困难的方面也有所改善。没有报告症状恶化的情况。
手术 100%解决了甲状腺功能亢进症，使患者的生活质量提高了约 70%。因此，手术可以立即有效地解决格雷夫斯病，并带来健康相关生活质量的改善。
