Mazerkina N A, Trunin Iu Iu, Gorelyshev S K, Golovanov A V, Kadasev B A, Shishkina L V, Rotin D A, Karmanov M E, Orlova E M
Zh Vopr Neirokhir Im N N Burdenko. 2012;76(5):63-8; discussion 69.
We present a case of 11-year old boy with Type 1 Autoimmune Polyglandular Syndrome and thyrotropin secreting pituitary adenoma, which was diagnosed by elevated TSH and thyroid hormones levels and MRI signs of pituitary tumor and without clinical symptoms of hyperthyroidism. He underwent partial resection of the tumor via transnasal approach and subsequent radiation therapy. Consequently 1 year after XRT patient developed growth hormone deficiency, 3.5 years later patient became euthyroid, and 5.5 years after treatment - hypothyroid. This is the first described case of coexistence of this 2 rare endocrine diseases in the same patient.
我们报告一例11岁男孩，患有1型自身免疫性多腺体综合征和促甲状腺激素分泌型垂体腺瘤，通过促甲状腺激素（TSH）和甲状腺激素水平升高以及垂体瘤的磁共振成像（MRI）征象确诊，且无甲状腺功能亢进的临床症状。他通过经鼻入路接受了肿瘤部分切除术及后续放疗。因此，放疗后1年患者出现生长激素缺乏，3.5年后甲状腺功能恢复正常，治疗后5.5年出现甲状腺功能减退。这是首例报道的同一患者同时存在这两种罕见内分泌疾病的病例。
