血管生成素变体与华裔人群的帕金森病无关。
Angiogenin variants are not associated with Parkinson's disease in the ethnic Chinese population.
机构信息
Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
出版信息
Parkinsonism Relat Disord. 2013 Apr;19(4):446-7. doi: 10.1016/j.parkreldis.2012.11.016. Epub 2012 Dec 8.
Recently, the angiogenin gene has been reported to be significantly associated with Parkinson's disease and amyotrophic lateral sclerosis in populations of European and American ancestry. But there have been no studies investigating the association between angiogenin and Parkinson's disease in the ethnic Chinese population. We conducted a case-control study to evaluate the association between angiogenin and Parkinson's disease in a Chinese population from mainland China. We sequenced the exons of angiogenin in 532 Parkinson's disease patients and 480 controls. We did not detect an angiogenin coding region mutation in either the patients or the controls. Our data do not support the association of angiogenin variants with PD in Han Chinese of mainland China.
最近，有研究报道血管生成素基因与欧洲和美国人群的帕金森病和肌萎缩侧索硬化显著相关。但是，目前还没有研究调查血管生成素与中国人群帕金森病之间的关系。我们进行了一项病例对照研究，以评估血管生成素与中国大陆汉族人群帕金森病之间的关系。我们对 532 名帕金森病患者和 480 名对照者的血管生成素外显子进行了测序。我们在患者或对照者中均未检测到血管生成素编码区突变。我们的数据不支持血管生成素变异与中国大陆汉族人群 PD 的关联。
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