Bouvier M, Grimaud J C, Abysique A
Laboratoire de Neurobiologie du C.N.R.S., Marseille, France.
Gastroenterology. 1990 May;98(5 Pt 1):1148-54. doi: 10.1016/0016-5085(90)90327-w.
The effects of distension and isovolumetric contraction of urinary bladder on colonic motility were studied in anesthetized cats. Distension and contraction of the urinary bladder induced an inhibition of spontaneous colonic electromyographic activity and a decrease in the amplitudes of the excitatory junction potentials evoked in the colon by stimulation of the distal end of the parasympathetic nerve fibers. This inhibition was blocked by guanethidine and phentolamine. Reversely, vesical emptying resulted in an increase in colonic motility, abolished by atropine, and an increase in the amplitude of the excitatory junction potentials. Both excitatory and inhibitory reflexes disappeared after hexamethonium. The inhibitory effects of bladder distension were abolished by bilateral section of the lumbar ventral or dorsal spinal roots and after bilateral section of the lumbar colonic or hypogastric nerves. These results indicate (a) that the vesical afferents responsible for the inhibitory and excitatory reflexes run in the hypogastric and pelvic nerves respectively and (b) that the inhibitory and excitatory effects are caused by the activation of sympathetic and parasympathetic efferent nerve fibers, respectively. The supraspinal nervous structures were not implicated in these reflexes because they persisted in spinal cats.
在麻醉猫身上研究了膀胱扩张和等容收缩对结肠运动的影响。膀胱扩张和收缩可抑制结肠自发性肌电图活动，并降低刺激副交感神经纤维远端时结肠中诱发的兴奋性接头电位的幅度。这种抑制作用可被胍乙啶和酚妥拉明阻断。相反，膀胱排空导致结肠运动增加，阿托品可消除这种增加，同时兴奋性接头电位的幅度也增加。六甲铵处理后，兴奋性和抑制性反射均消失。双侧切断腰腹侧或背侧脊髓神经根以及双侧切断腰结肠神经或腹下神经后，膀胱扩张的抑制作用消失。这些结果表明：（a）负责抑制性和兴奋性反射的膀胱传入神经分别走行于腹下神经和盆神经中；（b）抑制性和兴奋性效应分别由交感和副交感传出神经纤维的激活引起。脊髓上神经结构与这些反射无关，因为这些反射在脊髓猫中仍然存在。
