Taylor Clive R, Siddiqi Imran N, Brody Garry S
Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Appl Immunohistochem Mol Morphol. 2013 Jan;21(1):13-20. doi: 10.1097/PAI.0b013e318266476c.
Primary lymphomas of the breast are uncommon, and mostly of B-cell type. In the late 1990s, reports began to appear,primarily in the Pathology literature, of an apparently new category of breast lymphoma of T-cell type, having a particular association with silicone breast implants. This condition came to be recognized as implant-associated anaplastic large cell lymphoma.Appearing initially as individual case reports, the pathologic features were somewhat variable and the diagnosis was difficult. This review describes the pathologic and immunohistochemical features of implant-associated anaplastic large cell lymphoma of the breast drawn from a series of 103 cases. Recommendations are given for the management of removed implants, for the approach to differential diagnosis and the choice of initial immunohistochemical panels.
原发性乳腺淋巴瘤并不常见，且大多为B细胞型。在20世纪90年代后期，主要在病理学文献中开始出现报道，称有一种明显新型的T细胞型乳腺淋巴瘤，与硅凝胶乳房植入物有特定关联。这种情况后来被确认为植入物相关间变性大细胞淋巴瘤。最初以个案报道形式出现时，其病理特征有些多变，诊断困难。本综述描述了从103例病例系列中得出的乳腺植入物相关间变性大细胞淋巴瘤的病理和免疫组化特征。针对取出植入物的处理、鉴别诊断方法以及初始免疫组化检测项目的选择给出了建议。
