Department of Chemical Engineering and Materials Science/Fuel Cell Center, Yuan Ze University, Chung-Li City, Taiwan 320, Republic of China.
Curr Med Chem. 2012;19(30):5199-204. doi: 10.2174/092986712803530584.
Magnetic nanocomposites (MNCs) have highly been acknowledged in the diagnostics and therapeutic applications. Particularly, the multifunctional MNCs have brought a variety of possibilities in targeted drug delivery as well as non-invasive multimodality imaging. A temperature-responsive magnetic drug delivery system has been developed which is made up of superparamagnetic iron oxide nanoparticles (SIONPs) core and Pluronic shell. The magnetic cores composed of congo red conjugated to SIONPs have been proved beneficial as multimodal imaging agents, while superparamagnetic properties facile conducting the nano or micro systems to the vicinity of targeted tissue. Polymer shell formed by stimuli-responsive Pluronic F127 poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) PEO-PPO-PEO block copolymer serves as the carrier for both hydrophilic and hydrophobic drugs. X-ray diffraction (XRD) and high-resolution transmission electron microscope (HR-TEM) were used to characterize as-synthesized MNCs. Furthermore, vibrating magnetometer experiments showed MNCs having a higher magnetization value than bare magnetic nanoparticles (MNPs) and easy to conduct with an external magnetic field. The hydrodynamic size of MNCs was found to be varying in response to the stimuli temperature. Once the temperature increased, the hydrodynamic radius of MNCs decreased. In addition, the feasibility of the system as a targeted drug delivery system for Alzheimer's diseases (AD) diagnosis and therapy was studied. Searching for reliable targeting molecule, recent approaches for identification of amyloid-β (Aβ) and its derivatives have been evaluated. Consequently, the amyloid-derived diffusible ligands antibodies (anti-ADDLs) have been nominated as potential targeting molecules which can be attached to the MNCs system. The possibility of anti-ADDLs conjugation to DDS has been found promising for the multifunctional drug delivery system for AD diagnosis and therapy. However, further experimental studies are required to assess the performance of the proposed DDS.
磁性纳米复合材料（MNCs）在诊断和治疗应用中得到了高度认可。特别是，多功能 MNCs 在靶向药物输送以及非侵入性多模态成像方面带来了多种可能性。已经开发出一种温度响应磁性药物输送系统，该系统由超顺磁氧化铁纳米颗粒（SIONPs）核心和 Pluronic 壳组成。已经证明由 Congo 红共轭到 SIONPs 的磁性核作为多模态成像剂是有益的，而超顺磁性特性则便于将纳米或微系统引导至靶向组织附近。由刺激响应性 Pluronic F127 聚（环氧乙烷）-聚（环氧丙烷）-聚（环氧乙烷）PEO-PPO-PEO 嵌段共聚物形成的聚合物壳用作亲水性和疏水性药物的载体。X 射线衍射（XRD）和高分辨率透射电子显微镜（HR-TEM）用于表征合成的 MNCs。此外，振动磁强计实验表明，MNCs 的磁化值高于裸磁性纳米颗粒（MNPs），并且易于在外磁场中引导。MNCs 的水动力尺寸发现会响应刺激温度而变化。一旦温度升高，MNCs 的水动力半径就会减小。此外，还研究了该系统作为阿尔茨海默病（AD）诊断和治疗的靶向药物输送系统的可行性。为了寻找可靠的靶向分子，最近评估了鉴定淀粉样蛋白-β（Aβ）及其衍生物的方法。因此，淀粉样蛋白衍生的可扩散配体抗体（抗-ADDLs）被提名作为潜在的靶向分子，可以将其连接到 MNCs 系统上。已经发现抗-ADDLs 与 DDS 的结合对于 AD 诊断和治疗的多功能药物输送系统具有很大的可能性。然而，需要进一步的实验研究来评估所提出的 DDS 的性能。
