Schmitt C, Matulic M, Kervégant M, Tichadou L, Boutin A, Glaizal M, de Haro L
Centre Antipoison, hôpital Salvator, 249, boulevard St-Marguerite, 13009 Marseille, France.
Ann Dermatol Venereol. 2012 Dec;139(12):824-7. doi: 10.1016/j.annder.2012.06.035. Epub 2012 Sep 5.
Emla(®) cream, a mixture of two local anaesthetics (prilocaine 2.5%, lidocaine 2.5%) has a good benefit-risk profile. However, methaemoglobinaemia can occur, especially when the cream is applied in excessive amounts or over long periods.
The authors report a case of seizure and respiratory disturbances (MetHb=20.1%) after excessive application of Emla(®) (30g) for curettage of molluscum contagiosum in a young girl with eczema. The patient's clinical condition improved after withdrawal of the cream and administration of methylene blue, and she returned home on day two.
This new case of methaemoglobinaemia in a child following application of Emla(®) cream highlights the importance of strict compliance with the instructions for use of this medicinal product.
复方利多卡因乳膏（Emla®乳膏）是两种局部麻醉剂（丙胺卡因2.5%，利多卡因2.5%）的混合物，具有良好的效益风险比。然而，可能会发生高铁血红蛋白血症，尤其是当过量使用该乳膏或长期使用时。
作者报告了一名患有湿疹的年轻女孩在过量使用复方利多卡因乳膏（30克）刮除传染性软疣后出现癫痫发作和呼吸紊乱（高铁血红蛋白水平=20.1%）的病例。停用该乳膏并给予亚甲蓝后，患者的临床状况有所改善，并于第二天出院回家。
这例复方利多卡因乳膏使用后儿童发生高铁血红蛋白血症的新病例凸显了严格遵守该药品使用说明的重要性。
