Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Nanjing Medical University, No,121 Jiang jia yuan, Nanjing 210011, China.
Diagn Pathol. 2012 Dec 13;7:178. doi: 10.1186/1746-1596-7-178.
Latent membrane protein (LMP) 1 and LMP2A encoded by Epstein-Barr virus (EBV) are associated with the development of malignancies, but their expression in extranodal NK/T-cell lymphoma, nasal type (ENKTL) and the relationship with clinical characteristics of this disease remain poorly understood. In the present study, we examined the expression of LMP1 and LMP2A in ENKTL, and investigated the correlations between LMP1 and LMP2A expression with clinicopathological characteristics of ENKTL patients.
Paraffin sections of surgically removed samples from 16 ENKTL patients were analyzed by immunohistochemistry and the related clinicopathological data were collected and analyzed.
Elevated expression (immunohistochemistry score ≥ 4) of LMP1 and LMP2A was detected in the tumor cells of ENKTL. High LMP1 expression was associated with positive B symptoms (p = 0.012), while high LMP2A expression was related to gender (p = 0.029). The expression of both LMP1 and LMP2A showed significant correlations with patients' overall survival (p = 0.049, p = 0.036).
LMP1 and LMP2A may be prognostic indicators of survival in patients with ENKTL.
http://www.diagnosticpathology.diagnomx.eu/vs/2443352538545899.
Epstein-Barr 病毒（EBV）编码的潜伏膜蛋白（LMP）1 和 LMP2A 与恶性肿瘤的发展有关，但它们在结外 NK/T 细胞淋巴瘤，鼻型（ENKTL）中的表达及其与该病临床特征的关系尚不清楚。在本研究中，我们检测了 LMP1 和 LMP2A 在 ENKTL 中的表达，并研究了 LMP1 和 LMP2A 表达与 ENKTL 患者临床病理特征之间的相关性。
对 16 例 ENKTL 患者手术切除标本的石蜡切片进行免疫组织化学分析，并收集和分析相关临床病理资料。
在 ENKTL 的肿瘤细胞中检测到 LMP1 和 LMP2A 的高表达（免疫组织化学评分≥4）。高 LMP1 表达与阳性 B 症状相关（p=0.012），而高 LMP2A 表达与性别相关（p=0.029）。LMP1 和 LMP2A 的表达均与患者的总生存时间显著相关（p=0.049，p=0.036）。
LMP1 和 LMP2A 可能是 ENKTL 患者生存的预后指标。
