Center of Reproductive Medicine, The West China Second University Hospital, Sichuan University, Sichuan, PR China.
Gene. 2013 Feb 15;515(1):49-55. doi: 10.1016/j.gene.2012.11.037. Epub 2012 Dec 10.
To investigate the influence of the interleukin-10 gene promoter polymorphisms on the susceptibility of endometriosis, we examined the association by performing a meta-analysis. The PubMed, Embase, HuGE Navigator and CNKI were searched to identify eligible studies. We then conducted a meta-analysis to examine the association between interleukin-10 gene promoter polymorphisms and endometriosis. Eight case-control studies which examined the association between the IL-10 gene promoter polymorphisms and the susceptibility to endometriosis were finally included in the meta-analysis. Meta-analysis of the IL-10 -592 A/C polymorphisms showed a significant increased risk of endometriosis in the overall and Asian population in all genetic models and allele contrast. However, meta-analysis of the IL-10 -1082 A/G and IL-10 -819 T/C polymorphisms showed no association with endometriosis in all genetic models and allele contrast in the overall and Asian population samples. In addition, there was not a significant association between the IL-10 -592 A/C gene promoter polymorphisms with the severity of endometriosis. In conclusion, this meta-analysis suggests that the IL-10 -592 A/C polymorphisms conferred susceptibility to endometriosis. However, no associations were found between the IL-10 -1082 A/G and -819 T/C polymorphisms and susceptibility to endometriosis. Further studies are required to elucidate these associations more clearly.
为了研究白细胞介素-10 基因启动子多态性对子宫内膜异位症易感性的影响，我们通过荟萃分析来研究这种相关性。我们检索了 PubMed、Embase、HuGE Navigator 和 CNKI，以确定符合条件的研究。然后，我们进行了荟萃分析，以研究白细胞介素-10 基因启动子多态性与子宫内膜异位症之间的关系。最终，有 8 项病例对照研究纳入了荟萃分析，这些研究检查了 IL-10 基因启动子多态性与子宫内膜异位症易感性之间的关系。IL-10-592A/C 多态性的荟萃分析显示，在所有遗传模型和等位基因对比中，IL-10-592A/C 多态性与子宫内膜异位症的总体和亚洲人群的风险显著增加。然而，在所有遗传模型和等位基因对比中，IL-10-1082A/G 和 IL-10-819T/C 多态性的荟萃分析显示，它们与子宫内膜异位症之间没有关联，无论是在总体人群还是亚洲人群中。此外，IL-10-592A/C 基因启动子多态性与子宫内膜异位症的严重程度之间也没有显著的相关性。总之，这项荟萃分析表明，IL-10-592A/C 多态性与子宫内膜异位症的易感性有关。然而，IL-10-1082A/G 和-819T/C 多态性与子宫内膜异位症的易感性之间没有关联。需要进一步的研究来更清楚地阐明这些关联。
