他汀类药物治疗与成年女性患糖尿病的风险：益处是否大于风险？
Statin therapy and the risk for diabetes among adult women: do the benefits outweigh the risk?
作者信息
Ma Yunsheng, Culver Annie, Rossouw Jacques, Olendzki Barbara, Merriam Philip, Lian Bill, Ockene Ira
机构信息
Associate Professor of Medicine, Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA.
出版信息
Ther Adv Cardiovasc Dis. 2013 Feb;7(1):41-4. doi: 10.1177/1753944712468499. Epub 2012 Dec 13.
PURPOSE OF REVIEW
The purpose of this review was to examine statin therapy and the risk for diabetes among adult women using a selective review.
RECENT FINDINGS
The literature contains reports of new-onset diabetes associated with statin use. While many studies do not report sex-specific results, there is evidence indicating the risk to benefit ratio may vary by gender. However, the absolute effects are not clear because women have historically been under-represented in clinical trials.
SUMMARY
A review of the literature indicates that the cardiovascular benefits of statins appear to outweigh the risk for statin-related diabetes. However, the effect may depend upon baseline diabetes risk, dose, and statin potency. Rigorous, long-term studies focused on the risks and benefits of statins in women are unavailable to sort for gender-specific differences. Until this changes, individualized attention to risk assessment, and strong prevention with lifestyle changes must prevail.
综述目的
本综述旨在通过选择性回顾研究他汀类药物治疗与成年女性患糖尿病风险之间的关系。
最新研究发现
文献中有关于他汀类药物使用与新发糖尿病相关的报道。虽然许多研究未报告性别特异性结果，但有证据表明风险效益比可能因性别而异。然而，由于历史上女性在临床试验中的代表性不足，绝对影响尚不清楚。
总结
文献综述表明，他汀类药物对心血管的益处似乎超过了与他汀类药物相关的糖尿病风险。然而，这种影响可能取决于基线糖尿病风险、剂量和他汀类药物的效力。目前尚无针对他汀类药物在女性中的风险和益处的严格长期研究来区分性别特异性差异。在此情况改变之前，必须优先对风险评估给予个性化关注，并通过改变生活方式进行有力预防。
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