Department of Cell Biology, Institute of Biology, UNICAMP, Campinas, São Paulo, Brazil.
Exp Biol Med (Maywood). 2012 Nov;237(11):1298-309. doi: 10.1258/ebm.2012.012051.
The development of the prostate depends on a precise androgenic control, so sensible interferences may predispose this gland to develop prostatic diseases during life. These aspects are of interest and preoccupation, since human beings are exposed to a growing number of endocrine-disrupting chemicals with androgenic potential. Therefore, our aim was to evaluate the prostates of adult gerbils exposed to testosterone during intrauterine life. Serological, morphological, morphometric-stereologic, immunohistochemical and three-dimensional reconstruction analyses were used. We found that the testosterone effects were dose-dependent and more harmful to females, leading to the development of masculine characteristics, evidenced by an increased anogenital distance, and absence of vaginal opening and the ectopic development of prostatic tissue. Moreover, premalignant lesions, such as prostatic intraepithelial neoplasia, were observed in addition to inflammatory foci in the prostate. The results showed that the prenatal exposure to testosterone may affect the reproductive system, disrupting developmental processes and increasing susceptibility to the development of prostatic diseases in the Mongolian gerbil.
前列腺的发育依赖于雄激素的精确控制，因此，合理的干扰可能会使这种腺体在生命过程中容易患上前列腺疾病。这些方面是令人感兴趣和关注的，因为人类接触到越来越多具有雄激素潜能的内分泌干扰化学物质。因此，我们的目的是评估暴露于睾丸酮的成年沙鼠的前列腺。使用了血清学、形态学、形态计量立体学、免疫组织化学和三维重建分析。我们发现，睾丸酮的作用具有剂量依赖性，对雌性更有害，导致雄性特征的发展，表现为增加的肛殖距，阴道开口缺失和前列腺组织的异位发育。此外，还观察到前列腺上皮内瘤等癌前病变，以及前列腺中的炎症灶。结果表明，产前暴露于睾丸酮可能会影响生殖系统，扰乱发育过程，并增加蒙古沙鼠患前列腺疾病的易感性。
