Lin Yu-Cheng, Chen Pau-Chung
Fu-Jen Catholic University, New Taipei City, Taiwan En Chu Kong Hospital, New Taipei City, Taiwan National Taiwan University, Taipei, Taiwan.
National Taiwan University, Taipei, Taiwan National Taiwan University Hospital, Taipei, Taiwan
Asia Pac J Public Health. 2015 Mar;27(2):NP1765-74. doi: 10.1177/1010539512469248. Epub 2012 Dec 13.
To investigate the relationship between elevated serum alanine-transaminase (e-ALT) and persistent rotating shift work (p-RSW) among employees with sonographic fatty liver (SFL), the authors performed a retrospective analysis on a cohort of electronics manufacturing workers. The records of 758 workers (507 men, 251 women) with initially normal ALT and a mean age of 32.9 years were analyzed. A total of 109 workers (14.4%) developed e-ALT after 5 years. Compared with those having neither initial SFL nor p-RSW exposure, multivariate analysis indicated that employees who had initial SFL but without p-RSW finally had a higher risk (odds ratio = 2.9; 95% confidence interval [CI] = 1.7-5.1) for developing e-ALT; workers with baseline SFL plus p-RSW had a 3.7-fold increased risk (95% CI = 1.8-7.5). SFL poses a conspicuous risk for the development of e-ALT, and persistent p-RSW exposure significantly aggravates the development of e-ALT among on-site workers with preexisting SFL.
为了研究超声诊断为脂肪肝（SFL）的员工中血清丙氨酸转氨酶升高（e-ALT）与持续轮班工作（p-RSW）之间的关系，作者对一组电子制造工人进行了回顾性分析。分析了758名初始ALT正常、平均年龄为32.9岁的工人（507名男性，251名女性）的记录。5年后，共有109名工人（14.4%）出现了e-ALT。与既无初始SFL也无p-RSW暴露的工人相比，多因素分析表明，初始有SFL但无p-RSW的员工最终发生e-ALT的风险更高（比值比=2.9；95%置信区间[CI]=1.7-5.1）；基线有SFL加p-RSW的工人风险增加3.7倍（95%CI=1.8-7.5）。SFL是发生e-ALT的显著风险因素，持续的p-RSW暴露会显著加重已有SFL的现场工人发生e-ALT的情况。
