Hukowska-Szematowicz Beata, Tokarz-Deptuła Beata, Deptuła Wiesław
Department of Immunology, Faculty of Biology, University of Szczecin, Szczecin, Poland.
Acta Biochim Pol. 2012;59(4):459-65. Epub 2012 Dec 13.
Rabbit haemorrhagic disease virus (RHDV) belongs to the family Caliciviridae and is the etiological agent of the haemorrhagic disease, also known as rabbit plague. Its genome is a linear single-stranded (ss) RNA of 7437 nucleotides and the capsid is built from a single structural protein VP60. In connection with the discovery of new RHDV strains, there is a constant need to investigate the genetic variation of this virus and perform phylogenetic analyses which may show the evolutionary relationships among the RHDV strains. Studies on the divergence of RHDV have shown that it is genetically quite stable, although recent observations indicate that some new RHDV strains, significantly different from the original RHDV subtype and the new RHDVa subtype, are appearing. These latest findings suggest that a new group of RHDV strains has evolved. The present review summarizes the current knowledge on the genetic variation and the latest achievements in phylogenetic analyses of RHDV strains isolated in various countries.
兔出血症病毒（RHDV）属于杯状病毒科，是出血性疾病（又称兔瘟）的病原体。其基因组是一条由7437个核苷酸组成的线性单链（ss）RNA，衣壳由单一结构蛋白VP60构成。随着新的RHDV毒株的发现，持续需要研究该病毒的遗传变异并进行系统发育分析，以揭示RHDV毒株之间的进化关系。对RHDV分化的研究表明，它在基因上相当稳定，尽管最近的观察表明，一些与原始RHDV亚型和新的RHDVa亚型有显著差异的新RHDV毒株正在出现。这些最新发现表明，一组新的RHDV毒株已经进化出来。本综述总结了目前关于RHDV毒株遗传变异的知识以及在各国分离的RHDV毒株系统发育分析方面的最新成果。
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