OEM Jae-Ku, LEE Kwang-Nyeong, ROH In Soon, LEE Kyoung-Ki, KIM Seong-Hee, KIM Hye-Ryoung, PARK Choi-Kyu, JOO Yi-Seok
National Veterinary Research and Quarantine Service, Ministry of Agriculture, Animal Disease Diagnostic Center Division, Anayang, Republic of Korea.
J Vet Med Sci. 2009 Nov;71(11):1519-23. doi: 10.1292/jvms.001519.
Nine isolates of rabbit hemorrhagic disease virus (RHDV) were used for the genetic characterization of RHDV strains collected from rabbits in Korea between 2006 and 2008. A phylogenetic analysis of the complete VP60 region was performed and the sequences were divided mainly into two groups. The one group consisted of original RHDV and the other contained antigenic variant strain known as RHDVa strains. Most of the Korean isolates clustered with Chinese RHDV strains and belonged to the RHDVa subtype. A comparison of the amino acid sequences among RHDVa strains and original RHDV strains revealed significant substitutions of two amino acids in the A region, two in the B region, two in the F region, and nine amino acids in the E region. Taken together, the recent RHDVa strains have gradually replaced the original RHDV and are the predominant strains in Korea.
利用9株兔出血症病毒（RHDV）对2006年至2008年期间从韩国兔子中收集的RHDV毒株进行基因特征分析。对完整的VP60区域进行了系统发育分析，序列主要分为两组。一组由原始RHDV组成，另一组包含被称为RHDVa毒株的抗原变异株。大多数韩国分离株与中国RHDV毒株聚类，属于RHDVa亚型。对RHDVa毒株和原始RHDV毒株之间的氨基酸序列比较显示，A区域有两个氨基酸、B区域有两个氨基酸、F区域有两个氨基酸以及E区域有九个氨基酸发生了显著替换。综上所述，近期的RHDVa毒株已逐渐取代原始RHDV，成为韩国的主要毒株。
