Bosis S, Semino M, Picciolli I, Pinzani R, Genitori L, Principi N, Esposito S
Pediatric Clinic 1, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
J Prev Med Hyg. 2012 Jun;53(2):98-100.
Despite the availability of effective antibacterial agents and vaccines, pneumococcal meningitis and sepsis are still associated with high mortality rates and a high risk of neurological sequelae. We describe the case of a 17-month-old boy vaccinated with heptavalent pneumococcal conjugate vaccine (PCV7) who developed bacterial meningitis complicated by subdural empyema and deafness caused by Streptococcus pneumoniae serotype 7F. The 7F strain is not contained in PCV7 (the only vaccine on the market at the time of the onset of meningitis) but is included in the new pediatric 13-valent PCV, which may therefore prevent cases such as this in the future.
尽管有有效的抗菌药物和疫苗,但肺炎球菌性脑膜炎和败血症的死亡率仍然很高,并且存在很高的神经后遗症风险。我们描述了一名17个月大男孩的病例,他接种了七价肺炎球菌结合疫苗(PCV7),却患上了细菌性脑膜炎,并伴有硬膜下积脓和由7F血清型肺炎链球菌引起的耳聋。7F菌株并不包含在PCV7中(脑膜炎发病时市场上唯一的疫苗),但包含在新的儿科13价肺炎球菌结合疫苗中,因此这种疫苗未来可能预防此类病例的发生。