Rochat T S, Janssens J-P
Service de médecine interne générale, HUG, 1211 Genève 14.
Rev Med Suisse. 2012 Nov 21;8(363):2219-23.
The use of inhaled corticosteroids (ICS) is an important component of asthma management. Although their main impact is on airway inflammation, ICS are not devoid of systemic side effects (adrenal insufficiency, osteoporosis, brittle skin, ocular effects, growth retardation). Oropharyngeal side effects are also reported. These effects appear dose and duration dependent. They also vary according to the type of ICS used, its method of administration and drug interactions. It is recommended to titrate ICS to the lowest effective dose, to regularly reconsider their indication and to be aware of drug interactions. In addition, a change in ICS may have a favorable impact on side effects.
吸入性糖皮质激素（ICS）的使用是哮喘管理的重要组成部分。尽管其主要作用是针对气道炎症，但ICS并非没有全身性副作用（肾上腺功能不全、骨质疏松、皮肤脆弱、眼部影响、生长发育迟缓）。也有关于口咽部副作用的报道。这些副作用似乎与剂量和使用时长有关。它们还因所使用的ICS类型、给药方法以及药物相互作用而有所不同。建议将ICS滴定至最低有效剂量，定期重新评估其适应证，并注意药物相互作用。此外，更换ICS可能对副作用产生有利影响。
