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The promise of dual targeting Akt/mTOR signaling in lethal prostate cancer.

作者信息

Floc'h Nicolas, Abate-Shen Cory

出版信息

Oncotarget. 2012 Dec;3(12):1483-4. doi: 10.18632/oncotarget.771.

DOI:10.18632/oncotarget.771
PMID:23242005
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3681479/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c9a/3681479/e286b3888dba/oncotarget-03-1483-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c9a/3681479/e286b3888dba/oncotarget-03-1483-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c9a/3681479/e286b3888dba/oncotarget-03-1483-g001.jpg

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本文引用的文献

1
Increased survival with enzalutamide in prostate cancer after chemotherapy.恩杂鲁胺可提高化疗后前列腺癌患者的生存率。
N Engl J Med. 2012 Sep 27;367(13):1187-97. doi: 10.1056/NEJMoa1207506. Epub 2012 Aug 15.
2
Dual targeting of the Akt/mTOR signaling pathway inhibits castration-resistant prostate cancer in a genetically engineered mouse model.双重靶向 Akt/mTOR 信号通路抑制遗传工程小鼠模型中的去势抵抗性前列腺癌。
Cancer Res. 2012 Sep 1;72(17):4483-93. doi: 10.1158/0008-5472.CAN-12-0283. Epub 2012 Jul 19.
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Abiraterone and increased survival in metastatic prostate cancer.
Oncotarget. 2014 Sep 15;5(17):7217-59. doi: 10.18632/oncotarget.2406.
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Identification of novel therapeutic targets in the PI3K/AKT/mTOR pathway in hepatocellular carcinoma using targeted next generation sequencing.利用靶向二代测序技术鉴定肝细胞癌中PI3K/AKT/mTOR信号通路的新型治疗靶点
Oncotarget. 2014 May 30;5(10):3012-22. doi: 10.18632/oncotarget.1687.
5
Immunosuppressants in cancer prevention and therapy.癌症预防与治疗中的免疫抑制剂
Oncoimmunology. 2013 Dec 1;2(12):e26961. doi: 10.4161/onci.26961. Epub 2013 Nov 6.
6
TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists.从 TOR 角度探讨胰岛素抵抗与糖尿病并发症:内分泌学家和老年病学家的观点。
Cell Death Dis. 2013 Dec 12;4(12):e964. doi: 10.1038/cddis.2013.506.
7
Incidence and risk of treatment-related mortality with mTOR inhibitors everolimus and temsirolimus in cancer patients: a meta-analysis.癌症患者使用 mTOR 抑制剂依维莫司和替西罗莫司治疗相关死亡率的发生率和风险:一项荟萃分析。
PLoS One. 2013 Jun 13;8(6):e65166. doi: 10.1371/journal.pone.0065166. Print 2013.
阿比特龙与转移性前列腺癌患者的生存获益
N Engl J Med. 2011 May 26;364(21):1995-2005. doi: 10.1056/NEJMoa1014618.
4
Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer.PTEN 缺陷型前列腺癌中 PI3K 和雄激素受体信号的相互反馈调节。
Cancer Cell. 2011 May 17;19(5):575-86. doi: 10.1016/j.ccr.2011.04.008.
5
Sipuleucel-T immunotherapy for castration-resistant prostate cancer.西普利单抗免疫治疗去势抵抗性前列腺癌。
N Engl J Med. 2010 Jul 29;363(5):411-22. doi: 10.1056/NEJMoa1001294.
6
Integrative genomic profiling of human prostate cancer.人类前列腺癌的综合基因组分析。
Cancer Cell. 2010 Jul 13;18(1):11-22. doi: 10.1016/j.ccr.2010.05.026. Epub 2010 Jun 24.
7
Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis.去势抵抗性前列腺癌的生物学特性:针对雄激素受体信号轴的靶向治疗
J Clin Oncol. 2005 Nov 10;23(32):8253-61. doi: 10.1200/JCO.2005.03.4777.
8
Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer.多西他赛与雌莫司汀对比米托蒽醌和泼尼松治疗晚期难治性前列腺癌的疗效
N Engl J Med. 2004 Oct 7;351(15):1513-20. doi: 10.1056/NEJMoa041318.
9
Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer.多西他赛联合泼尼松或米托蒽醌联合泼尼松用于晚期前列腺癌治疗
N Engl J Med. 2004 Oct 7;351(15):1502-12. doi: 10.1056/NEJMoa040720.
10
Will mTOR inhibitors make it as cancer drugs?mTOR抑制剂能成为抗癌药物吗?
Cancer Cell. 2003 Nov;4(5):343-8. doi: 10.1016/s1535-6108(03)00275-7.