α-颗粒：一个正在形成的故事。
α-granules: a story in the making.
机构信息
Beth Israel Deaconess Medical Center.
出版信息
Blood. 2012 Dec 13;120(25):4908-9. doi: 10.1182/blood-2012-10-459115.
PMID:23243155
Abstract
α-granules are by far the most abundant platelet granules. Yet little is known about how they are formed. In this issue of Blood, Urban et al now characterize platelets from patients with an inheritable α-granule defect, demonstrating a role for VPS16B in α-granule biogenesis and taking us one step closer to understanding how these elusive organelles are formed.
摘要
α-颗粒是迄今为止血小板中含量最丰富的颗粒。然而，关于它们是如何形成的，我们知之甚少。在本期《Blood》杂志中，Urban 等人对患有遗传性 α-颗粒缺陷的患者的血小板进行了特征描述，证明了 VPS16B 在 α-颗粒生物发生中的作用，并使我们更深入地了解了这些难以捉摸的细胞器是如何形成的。
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