便捷的一步法合成具有药用相关性的苯并吡喃并吡啶体系。
Convenient one-step synthesis of a medicinally relevant benzopyranopyridine system.
作者信息
Evdokimov Nikolai M, Kireev Artem S, Yakovenko Andrey A, Antipin Mikhail Yu, Magedov Igor V, Kornienko Alexander
机构信息
Department of Organic Chemistry, Timiryazev Agriculture Academy, Moscow 127550, Russia.
出版信息
Tetrahedron Lett. 2006 Dec 25;47(52):9309-9312. doi: 10.1016/j.tetlet.2006.10.110.
Abstract
Benzopyrano[2,3-b]pyridine is an important privileged medicinal scaffold. A three-component reaction of salicylaldehydes, thiols and 2 equiv of malononitrile that leads to the formation of a series of compounds incorporating 2,4-diamino-3-cyano-5-sulfanylbenzopyrano[2,3-b]pyridine framework is described. A proposed mechanism with the supporting experimental data is presented.
摘要
苯并吡喃并[2,3 - b]吡啶是一种重要的优势药用骨架。本文描述了水杨醛、硫醇与2当量丙二腈的三组分反应，该反应可生成一系列包含2,4 - 二氨基 - 3 - 氰基 - 5 - 硫烷基苯并吡喃并[2,3 - b]吡啶骨架的化合物。同时还给出了一个带有支持性实验数据的推测机理。
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