Chemistry Centre, School of Sciences, University of Minho, Gualtar Campus, 4715-303 Braga, Portugal.
Centre for Textile Science and Technology (2C2T), University of Minho, Azurém Campus, 4800-058 Guimarães, Portugal.
Molecules. 2024 Jun 25;29(13):3004. doi: 10.3390/molecules29133004.
The chromenopyridine scaffold represents an important class of heterocyclic compounds exhibiting a broad spectrum of biological properties. This review describes novel and efficient procedures for the synthesis of this scaffold. Herein, several methods were detailed and grouped according to their starting material (e.g., salicylaldehydes, chromones, chromanones and coumarins) and respective biological activity, when reported. This review highlights the potential of the reported synthetic strategies for preparing chromenopyridine derivatives with promising biological activity, paving the way for further developments in drug discovery.
色烯并吡啶骨架代表了一类重要的杂环化合物，具有广泛的生物活性。本文综述了该骨架的新型高效合成方法。本文详细描述了几种方法，并根据其起始原料（例如水杨醛、色酮、色满酮和香豆素）和报道的相应生物活性进行了分组。本文综述强调了所报道的合成策略在制备具有潜在生物活性的色烯并吡啶衍生物方面的潜力，为药物发现的进一步发展铺平了道路。
