Department of Dermatology; Tohoku University Graduate School of Medicine; Sendai, Japan.
Oncoimmunology. 2012 Nov 1;1(8):1433-1434. doi: 10.4161/onci.21176.
Myeloid derived suppressor cells (MDSCa) are a heterogeneous population of cells that promote an immunosuppressive environment in tumor-bearing hosts. Recently, B7-H1 signaling has been reported to be critical for the maintainancer of regulatory T cells (Tregs), another immunosuppressive cell population. Here, we discuss the immunosuppressive function of B7-H1 on MDSCs, and the functional crosstalk between Tregs and MDSCs.
髓源抑制细胞(MDSC)是一种异质性细胞群体,可在荷瘤宿主中促进免疫抑制环境。最近,B7-H1 信号被报道对调节性 T 细胞(Treg)的维持至关重要,Treg 也是一种免疫抑制细胞群体。在这里,我们讨论了 B7-H1 对 MDSC 的免疫抑制功能,以及 Treg 和 MDSC 之间的功能串扰。