IRCCS Istituto delle Scienze Neurologiche Bologna, and Dipartimento di ScienzeBiomediche e NeuroMotorie, Alma Mater Studiorum Università di Bologna, Bologna, Italy.
Epilepsy Behav. 2013 Jan;26(1):114-7. doi: 10.1016/j.yebeh.2012.10.014. Epub 2012 Dec 12.
The beneficial effect of nicotine has been reported in autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) patients, but not tested in sporadic cases. Recently, a nicotine defect in the arousal pathway has been hypothesized even in sporadic NFLE patients and their relatives. This case-control family study was designed to test whether NFLE subjects were more likely to use tobacco than controls, as an indirect marker of cholinergic arousal system dysregulation. At least four relatives were included for each NFLE proband and control. Each subject was questioned about tobacco habits; 434 individuals were recruited. Moreover, we compared NFLE patients with age- and sex-matched controls to determine whether they are more likely to use tobacco. We found a slightly higher trend of tobacco use in NFLE probands compared to that in control subjects; we did not find any significant difference in the distribution of tobacco use among NFLE group compared to that in the control group.
已经有报道称尼古丁对常染色体显性夜间额叶癫痫（ADNFLE）患者有有益作用，但尚未在散发性病例中进行测试。最近，有人假设即使在散发性 NFLE 患者及其亲属中，也存在觉醒途径的尼古丁缺陷。这项病例对照家族研究旨在测试 NFLE 患者是否比对照组更有可能使用烟草，作为胆碱能觉醒系统失调的间接标志物。对于每个 NFLE 先证者和对照组，至少包括四个亲属。对每个受试者进行了关于吸烟习惯的询问；共招募了 434 人。此外，我们比较了年龄和性别匹配的 NFLE 患者和对照组，以确定他们是否更有可能吸烟。我们发现 NFLE 先证者比对照组更倾向于吸烟，但我们没有发现 NFLE 组与对照组在吸烟分布方面有任何显著差异。
