Department of Psychology, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8.
Epilepsy Behav. 2013 Jan;26(1):102-8. doi: 10.1016/j.yebeh.2012.11.003. Epub 2012 Dec 12.
The aim of the present study was to shed light on the executive functioning deficits that might differentiate children with frontal lobe epilepsy (FLE) from children with temporal lobe epilepsy (TLE). Participants included 19 youth with intractable FLE and 47 youth with intractable TLE. Participants completed the Wisconsin Card Sorting Test (WCST), verbal fluency, Trail Making Test (Trails A and B), Digit Span Forward (DSF), and Digit Span Backward (DSB). When compared to the normative sample, the FLE group performed significantly worse on DSF, DSB, Trails B, and the WCST. Similarly, the TLE group performed significantly worse on DSF and DSB compared to the normative sample. Youth with FLE had significantly greater difficulty on the WCST compared to the TLE group. Overall, the results indicated that youth with FLE had significantly greater difficulty with concept formation compared to children with TLE. No differences between groups emerged on tasks assessing attention, working memory, mental flexibility, or rapid word retrieval. Both groups performed significantly below the normative sample levels on attention and working memory tasks. As a whole, it appears that some, although not all, executive dysfunction is specific to FLE.
本研究旨在阐明可能区分额叶癫痫（FLE）和颞叶癫痫（TLE）儿童的执行功能缺陷。参与者包括 19 名难治性 FLE 青少年和 47 名难治性 TLE 青少年。参与者完成了威斯康星卡片分类测试（WCST）、言语流畅性、连线测试（Trails A 和 B）、数字跨度正向（DSF）和数字跨度反向（DSB）。与正常样本相比，FLE 组在 DSF、DSB、Trails B 和 WCST 上的表现明显更差。同样，与正常样本相比，TLE 组在 DSF 和 DSB 上的表现明显更差。与 TLE 组相比，FLE 组在 WCST 上的表现明显更困难。总的来说，结果表明，与 TLE 儿童相比，FLE 儿童在概念形成方面有明显更大的困难。两组在注意力、工作记忆、心理灵活性或快速单词检索等评估任务上均无差异。两组在注意力和工作记忆任务上的表现均明显低于正常样本水平。总的来说，似乎有些（尽管不是全部）执行功能障碍是 FLE 特有的。
