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早期叶绿体发育中的必需核质体蛋白。

Essential nucleoid proteins in early chloroplast development.

机构信息

Department of Plant Physiology, Institute of General Botany and Plant Physiology, Friedrich-Schiller-University Jena, Dornburger Str. 159, D-07743 Jena, Germany.

出版信息

Trends Plant Sci. 2013 Apr;18(4):186-94. doi: 10.1016/j.tplants.2012.11.003. Epub 2012 Dec 12.

Abstract

The plastid transcription machinery can be biochemically purified at different organisational levels as soluble RNA polymerase, transcriptionally active chromosome, or nucleoid. Recent proteomic studies have uncovered several novel proteins in these structures and functional genomic studies have indicated that a lack of many of these proteins results in chlorotic phenotypes of varying degree. The most severe cases exhibit complete albino phenotypes, which led to the conclusion that the proteins that were lacking had important regulatory roles in plastid gene expression and chloroplast development. In this opinion article, we propose an alternative model in which the structural establishment of a transcriptional subdomain within the nucleoid represents an early developmental bottleneck that leads to abortion of proper chloroplast biogenesis if disturbed.

摘要

质体转录机制可以在不同的组织水平上进行生化纯化,如可溶性 RNA 聚合酶、转录活性染色体或类核。最近的蛋白质组学研究在这些结构中发现了几种新的蛋白质,功能基因组学研究表明,这些蛋白质中的许多缺失会导致不同程度的黄化表型。最严重的情况表现出完全白化的表型,这导致了这样的结论,即缺失的蛋白质在质体基因表达和叶绿体发育中具有重要的调节作用。在这篇观点文章中,我们提出了一个替代模型,即类核内转录亚域的结构建立代表了早期发育的瓶颈,如果受到干扰,会导致适当的叶绿体发生发育失败。

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