维胺宁 A 及其类似物对 RBL-2H3 细胞肿瘤坏死因子-α释放和产生的抑制作用。
Inhibitory effects of vialinin A and its analog on tumor necrosis factor-α release and production from RBL-2H3 cells.
机构信息
Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan.
出版信息
Cell Immunol. 2012 Oct;279(2):140-4. doi: 10.1016/j.cellimm.2012.10.008. Epub 2012 Oct 29.
Vialinin A is an extremely potent inhibitor of tumor necrosis factor (TNF)-α release from RBL-2H3 cells. The present study investigated in detail the inhibitory effects of vialinin A and its analog, 5',6'-dimethyl-1,1':4',1″-terphenyl-2',3',4,4″-tetraol (DMT), on TNF-α. Vialinin A and DMT inhibited the release of TNF-α from RBL-2H3 cells in a dose-dependent manner, but had no effect on β-hexosaminidase activity. Also, vialinins had little effect on TNF-α mRNA levels. Intriguingly, vialinins inhibited TNF-α production at low concentrations, but not shown a dose-dependency. The potent inhibitory activities of vialinins against TNF-α production and release suggest promising new candidate pathways for anti-inflammatory agents.
Vialinin A 是一种强效的肿瘤坏死因子 (TNF)-α 释放抑制剂，本研究详细研究了 vialinin A 及其类似物 5'，6'-二甲基-1,1':4',1″-三联苯-2'，3'，4,4″-四醇 (DMT) 对 TNF-α 的抑制作用。Vialinin A 和 DMT 呈剂量依赖性抑制 RBL-2H3 细胞释放 TNF-α，但对β-己糖胺酶活性没有影响。此外，vialinins 对 TNF-α mRNA 水平影响不大。有趣的是，vialinins 在低浓度时抑制 TNF-α 的产生，但没有表现出剂量依赖性。Vialinins 对 TNF-α 产生和释放的强抑制活性表明，它们可能是一种有前途的新型抗炎药物作用途径。
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