Karl Landsteiner Institute for Clinical Epilepsy Research and Cognitive Neurology, 2nd Neurological Department, General Hospital Hietzing with Neurological Center Rosenhuegel, Vienna, Austria.
Epilepsy Behav. 2013 Jan;26(1):81-6. doi: 10.1016/j.yebeh.2012.06.022. Epub 2012 Dec 12.
Retrospective data analysis was performed in a sample of 45 consecutive patients who underwent epilepsy surgery for medically refractory mTLE-HS. Beck Depression Inventory (BDI) was used preoperatively to detect actual depressive symptoms and label patients into those "with depressive symptoms" or "without depressive symptoms". Postoperative seizure outcome one, two, and three years after surgery was classified into "complete seizure freedom" versus "presence of auras and/or seizures". Postoperative seizure outcomes were compared in patients with and without depressive symptoms, and no significant difference of postoperative seizure outcome was found. However, there was a non-significant trend for patients with preoperative depressive symptoms to experience a postoperative running down phenomenon more frequently than nondepressed patients. Depressive symptoms, identified by the BDI, do not seem to have a predictive value for postoperative seizure outcome in this highly selected patient population with mTLE-HS, but may be positive predictors for experiencing a postoperative running down phenomenon.
对 45 例接受药物难治性颞叶内侧硬化症（mTLE-HS）癫痫手术的连续患者进行回顾性数据分析。术前使用贝克抑郁量表（BDI）检测实际抑郁症状，并将患者分为“有抑郁症状”或“无抑郁症状”。术后 1、2、3 年的癫痫发作结果分为“完全无癫痫发作”与“先兆和/或癫痫发作存在”。比较有和无抑郁症状患者的术后癫痫发作结果，未发现术后癫痫发作结果存在显著差异。然而，术前有抑郁症状的患者比无抑郁症状的患者更频繁地出现术后衰退现象，这种趋势无统计学意义。在 mTLE-HS 这一高度选择的患者人群中，BDI 识别出的抑郁症状似乎对术后癫痫发作结果没有预测价值，但可能是经历术后衰退现象的阳性预测因子。
