Department of Psychiatry, Chinese University of Hong Kong, Hong Kong SAR, China.
Neurol Sci. 2013 Aug;34(8):1347-53. doi: 10.1007/s10072-012-1267-7. Epub 2012 Dec 18.
White matter hyperintensities (WMH) are common in stroke. The influence of WMH on health-related quality of life (HRQoL) following a lacunar stroke is unknown. This study evaluated the impact of WMH on HRQoL in acute lacunar stroke. A cohort of 160 patients with acute lacunar stroke admitted to the stroke unit of a university-affiliated regional hospital in Hong Kong was recruited. Three months after the index stroke, a research assistant administered the Short Form-36 (SF-36) to assess HRQoL. The severity of WMH was evaluated with magnetic resonance imaging (MRI). In univariate analysis, the severity of deep WMH (DWMH) negatively correlated with patients' vitality (VT; p < 0.05), social function (SF; p < 0.001), role-emotional (RE; p < 0.01), mental health (MH; p < 0.01), and mental component summary (MCS; p < 0.001) scores of HRQoL. DWMH was independently associated with all of the above five SF-36 scores (p < 0.05) in linear regression analysis. These findings suggest that DWMH has a significant impact on the HRQoL of stroke survivors. The importance of DWMH in the long-term HRQoL in lacunar stroke warrants further investigation.
脑白质高信号（WMH）在中风中很常见。WMH 对腔隙性中风后健康相关生活质量（HRQoL）的影响尚不清楚。本研究评估了 WMH 对急性腔隙性中风患者 HRQoL 的影响。一项队列研究纳入了香港一所大学附属医院中风病房收治的 160 例急性腔隙性中风患者。在指数中风后 3 个月，研究助理使用 SF-36 评估 HRQoL。采用磁共振成像（MRI）评估 WMH 严重程度。在单因素分析中，深部脑白质高信号（DWMH）的严重程度与患者的活力（VT；p < 0.05）、社会功能（SF；p < 0.001）、角色情绪（RE；p < 0.01）、心理健康（MH；p < 0.01）和精神健康综合评分（MCS；p < 0.001）呈负相关。多元线性回归分析显示，DWMH 与上述五个 SF-36 评分均独立相关（p < 0.05）。这些发现表明，DWMH 对中风幸存者的 HRQoL 有显著影响。DWMH 在腔隙性中风长期 HRQoL 中的重要性值得进一步研究。
