奎宁-硫脲催化的三氟甲基 2(1H)-喹唑啉酮的对映选择性氢膦酰化反应。
Quinine-thiourea catalyzed enantioselective hydrophosphonylation of trifluoromethyl 2(1H)-quinazolinones.
机构信息
Department of Chemistry and Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001, USA.
出版信息
Chem Commun (Camb). 2013 Jan 30;49(9):928-30. doi: 10.1039/c2cc38097h.
PMID:23248060
Abstract
An organocatalytic enantioselective addition reaction of cyclic ketoimines with phosphites has been developed for the first time. The process, catalyzed by Soós' quinine thiourea, affords synthetically and medicinally interesting enantioenriched trifluoromethyl dihydroquinazolinones in high yields and with high enantioselectivities.
摘要
首次发展了一种手性有机催化的环酮亚胺与亚膦酸酯的对映选择性加成反应。该过程由 Soós 的奎宁硫脲催化，以高产率和高对映选择性得到了具有合成和药物意义的手性富集的三氟甲基二氢喹唑啉酮。
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