供体淋巴细胞输注在伴有NPM1突变的急性髓系白血病中诱导多特异性CD8(+) T细胞反应并同时实现分子缓解。 - Suppr

Donor lymphocyte infusion induces polyspecific CD8(+) T-cell responses with concurrent molecular remission in acute myeloid leukemia with NPM1 mutation.

作者信息

Hofmann Susanne, Götz Marlies, Schneider Vanessa, Guillaume Philippe, Bunjes Donald, Döhner Hartmut, Wiesneth Markus, Greiner Jochen

机构信息

Universitiy Clinic Ulm, Department of Internal Medicine III, Albert-Einstein-Allee 23, Ulm, Germany 89081.

出版信息

J Clin Oncol. 2013 Jan 20;31(3):e44-7. doi: 10.1200/JCO.2011.41.1116. Epub 2012 Dec 17.

DOI:10.1200/JCO.2011.41.1116

PMID:23248243

Abstract

摘要

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Donor lymphocyte infusion induces polyspecific CD8(+) T-cell responses with concurrent molecular remission in acute myeloid leukemia with NPM1 mutation.供体淋巴细胞输注在伴有NPM1突变的急性髓系白血病中诱导多特异性CD8(+) T细胞反应并同时实现分子缓解。

J Clin Oncol. 2013 Jan 20;31(3):e44-7. doi: 10.1200/JCO.2011.41.1116. Epub 2012 Dec 17.

Potential role of adoptively transferred allogeneic WT1-specific CD4+ and CD8+ T lymphocytes for the sustained remission of refractory AML.过继转移的同种异体WT1特异性CD4+和CD8+ T淋巴细胞对难治性急性髓系白血病持续缓解的潜在作用。

Bone Marrow Transplant. 2010 Mar;45(3):597-9. doi: 10.1038/bmt.2009.191. Epub 2009 Aug 17.

Mutation of the NPM1 gene contributes to the development of donor cell-derived acute myeloid leukemia after unrelated cord blood transplantation for acute lymphoblastic leukemia.NPM1 基因突变导致无关脐带血移植治疗急性淋巴细胞白血病后供体细胞源性急性髓系白血病的发生。

Hum Pathol. 2013 Aug;44(8):1696-9. doi: 10.1016/j.humpath.2013.01.001. Epub 2013 Mar 1.

Longitudinal analyses of leukemia-associated antigen-specific CD8 T cells in patients after allogeneic stem cell transplantation.异基因造血干细胞移植后患者白血病相关抗原特异性CD8 T细胞的纵向分析。

Exp Hematol. 2016 Nov;44(11):1024-1033.e1. doi: 10.1016/j.exphem.2016.07.008. Epub 2016 Jul 26.

Neoantigen-Specific T-Cell Immune Responses: The Paradigm of NPM1-Mutated Acute Myeloid Leukemia.新抗原特异性 T 细胞免疫反应：NPM1 突变型急性髓系白血病的范例。

Int J Mol Sci. 2021 Aug 25;22(17):9159. doi: 10.3390/ijms22179159.

Molecular persistence of chronic myeloid leukemia caused by donor T cells specific for lineage-restricted maturation antigens not recognizing immature progenitor-cells.由针对谱系限制性成熟抗原的供体T细胞引起的慢性髓性白血病的分子持续性，这些抗原不识别未成熟祖细胞。

Leukemia. 2006 Jun;20(6):1040-6. doi: 10.1038/sj.leu.2404169.

Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia.细胞遗传学正常的急性髓系白血病中的突变与治疗结果

N Engl J Med. 2008 May 1;358(18):1909-18. doi: 10.1056/NEJMoa074306.

Minimal residual disease detection in acute myeloid leukemia by mutant nucleophosmin (NPM1): comparison with WT1 gene expression.通过突变型核磷蛋白（NPM1）检测急性髓系白血病中的微小残留病：与WT1基因表达的比较

Clin Chim Acta. 2008 Sep;395(1-2):120-3. doi: 10.1016/j.cca.2008.05.021. Epub 2008 Jun 8.

Clinical grade expansion of CD45RA, CD45RO, and CD62L-positive T-cell lines from HLA-compatible donors: high cytotoxic potential against AML and ALL cells.来自 HLA 相容供体的 CD45RA、CD45RO 和 CD62L 阳性 T 细胞系的临床级扩增：对急性髓系白血病和急性淋巴细胞白血病细胞具有高细胞毒性潜力。

Exp Hematol. 2006 Apr;34(4):475-85. doi: 10.1016/j.exphem.2005.12.012.

Immune responses against the mutated region of cytoplasmatic NPM1 might contribute to the favorable clinical outcome of AML patients with NPM1 mutations (NPM1mut).针对细胞质NPM1突变区域的免疫反应可能有助于NPM1突变（NPM1mut）的急性髓系白血病患者获得良好的临床结果。

Blood. 2013 Aug 8;122(6):1087-8. doi: 10.1182/blood-2013-04-496844.

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Cancers (Basel). 2024 Oct 10;16(20):3443. doi: 10.3390/cancers16203443.

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Nucleophosmin 1 cooperates with the methyltransferase DOT1L to preserve peri-nucleolar heterochromatin organization by regulating H3K27me3 levels and DNA repeats expression.核仁磷酸蛋白 1 通过调节 H3K27me3 水平和 DNA 重复序列的表达，与甲基转移酶 DOT1L 合作，维持核仁周异染色质的组织。

Epigenetics Chromatin. 2023 Sep 28;16(1):36. doi: 10.1186/s13072-023-00511-9.

HLA Class I Genotype Is Associated with Relapse Risk after Allogeneic Stem Cell Transplantation for NPM1-Mutated Acute Myeloid Leukemia.HLA Ⅰ类基因分型与 NPM1 突变型急性髓系白血病异基因造血干细胞移植后复发风险相关。

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Neoantigen-specific TCR-T cell-based immunotherapy for acute myeloid leukemia.基于新抗原特异性TCR-T细胞的急性髓系白血病免疫疗法。

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Int J Mol Sci. 2021 Aug 25;22(17):9159. doi: 10.3390/ijms22179159.

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Donor lymphocyte infusion induces polyspecific CD8(+) T-cell responses with concurrent molecular remission in acute myeloid leukemia with NPM1 mutation.

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