Institute of Pharmacology, Siberian Branch, Russian Academy of Medical Sciences, Lenin Avenue 3, 634028, Tomsk, Russian Federation, Russia.
Indian J Pharmacol. 2012 Nov-Dec;44(6):710-3. doi: 10.4103/0253-7613.103260.
In this study, we have evaluated the influence of antioxidant complex (AOC) (dihydroquercetin and lipoic acid) on pool of nonadhesive leukocytes and leukocytes with low and high adhesion in chronic venous insufficiency (CVI) of lower limbs in rats.
Model of CVI of lower limbs was created by blood flow restriction in caudal vena cava. AOC was administered at 100 mg/kg b.w./day for 14 days p.o. The venous pressure in vena cava and adhesion of leukocytes were estimated on the 14th day of the experiment.
On the 14th day, the venous pressure in groups of animals (experimental and control) was in 2.7-2.9-fold higher. In the control group, the significant increase of leukocytes pool with high adhesion was detected. Intragastric administration of AOC reduced the number of leukocytes with high adhesion and increased the number of nonadhesive leukocytes and leukocytes with a low adhesion.
Model of CVI of lower limb is accompanied by increased venous pressure and raised adhesion activity of leukocytes. Administration of AOC for 14 days reduces the adhesive activity of leukocytes.
本研究评估了抗氧化复合物（AOC）（二氢槲皮素和硫辛酸）对慢性静脉功能不全（CVI）下肢非黏附性白细胞和低、高黏附性白细胞池的影响。
通过尾腔静脉血流受限创建 CVI 模型。AOC 以 100mg/kg b.w./天的剂量经口给药 14 天。在实验的第 14 天，评估腔静脉静脉压和白细胞黏附情况。
在第 14 天，动物（实验组和对照组）的腔静脉静脉压升高了 2.7-2.9 倍。在对照组中，检测到高黏附性白细胞池显著增加。AOC 经胃给药可减少高黏附性白细胞数量，增加非黏附性白细胞和低黏附性白细胞数量。
下肢 CVI 模型伴有静脉压升高和白细胞黏附活性增强。AOC 给药 14 天可降低白细胞黏附活性。
