Raf激酶抑制蛋白表达降低与可切除非小细胞肺癌的淋巴结转移相关。
Reduction of Raf Kinase Inhibitor Protein Expression is Associated with Lymph Node Metastasis in Resectable Non-small Cell Lung Cancer.
作者信息
Yan Huang, Guoqiang Lin, Shengxi Chen, Zhenghao Deng, Lingjin Huang
机构信息
Department of Infectious Disease, Xiangya Hospital, Central South University, Xiangya Road, Changsha, China.
出版信息
Open Respir Med J. 2012;6:135-8. doi: 10.2174/1874306401206010135. Epub 2012 Nov 30.
INTRODUCTION
Raf kinase inhibitor protein (RKIP) had been identified as one of prognostic indictor in various malignant diseases. Association of RKIP expression and the clinical-pathological features were not investigated in patients with resectable non-small cell lung cancer (NSCLC).
MATERIALS AND METHODOLOGY
159 sectioned samples from surgical NSCLC patients were investigated by immunohistochemistry in order to reveal the associations between RKIP expression and clinical-pathologic features.
RESULTS
Statistically, Lower RKIP expression level was found in the group with higher N stage (P<0.01) and higher TNM stage (P<0.05). No significant correlation was observed between RKIP expressions and histologic type (P>0.05) and tumor size (P>0.05).
CONCLUSIONS
Down expression level of RKIP was found relating to lymph node metastasis in resectable NSCLC patients in this study.
引言
Raf激酶抑制蛋白（RKIP）已被确定为多种恶性疾病的预后指标之一。在可切除的非小细胞肺癌（NSCLC）患者中，尚未研究RKIP表达与临床病理特征之间的关联。
材料与方法
通过免疫组织化学对159例手术切除的NSCLC患者样本进行研究，以揭示RKIP表达与临床病理特征之间的关联。
结果
统计学分析显示，N分期较高（P<0.01）和TNM分期较高（P<0.05）的组中RKIP表达水平较低。RKIP表达与组织学类型（P>0.05）和肿瘤大小（P>0.05）之间未观察到显著相关性。
结论
本研究发现，可切除的NSCLC患者中RKIP表达水平降低与淋巴结转移有关。
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