常规补充L-抗坏血酸不会改变食用牛奶配方奶的低出生体重婴儿的铁、铜和锌平衡。

Routine L-ascorbic acid supplementation does not alter iron, copper, and zinc balance in low-birth-weight infants fed a cows'-milk formula.

作者信息

Stack T, Aggett P J, Aitken E, Lloyd D J

机构信息

Department of Child Health, University of Aberdeen, Scotland, U.K.

出版信息

J Pediatr Gastroenterol Nutr. 1990 Apr;10(3):351-6. doi: 10.1097/00005176-199004000-00015.

DOI:10.1097/00005176-199004000-00015

PMID:2324896

Abstract

The effect of ascorbic acid (AA) [284 mumol (50 mg) twice daily] on the net intestinal absorption and maximum apparent retention of Fe, Cu, and Zn was investigated by metabolic balance studies in a randomised crossover study of six low-birth-weight (LBW) neonates fed a cows'-milk-based formula containing (mumol/L) Fe, 126; Cu, 11; Zn, 87; and AA, 400. Absorption +/- SD (Fe, -5.0 +/- 7.5; Cu, 0 +/- 0.4; Zn, -0.8 +/- 3.4) (mumol kg-1 day-1) was not altered by AA (Fe, -4.1 +/- 4.6; Cu, 0.3 +/- 0.6; Zn, -1.1 +/- 2.7) neither was retention (without AA: Fe, -6.0 +/- 8.4; Cu, -0.1 +/- 0.3; Zn, -2.4 +/- 4.2; with AA: Fe, -4.9 +/- 4.7; Cu, 0.1 +/- 0.6; and Zn, -2.7 +/- 3.1). Supplements of AA administered as in the circumstances of routine care of LBW neonates do not enhance the absorption and retention of Fe, nor do they impair these aspects of the metabolism of Cu and Zn.

摘要

在一项随机交叉研究中，对6名低出生体重（LBW）新生儿进行代谢平衡研究，这些新生儿喂食以牛奶为基础的配方奶，其中每升含有（微摩尔/升）铁126、铜11、锌87和抗坏血酸（AA）400，以此来研究抗坏血酸（AA）[每天两次，每次284微摩尔（50毫克）]对铁、铜和锌的肠道净吸收及最大表观潴留的影响。抗坏血酸并未改变吸收情况±标准差（铁，-5.0±7.5；铜，0±0.4；锌，-0.8±3.4）（微摩尔/千克/天）（抗坏血酸组：铁，-4.1±4.6；铜，0.3±0.6；锌，-1.1±2.7），也未改变潴留情况（无抗坏血酸组：铁，-6.0±8.4；铜，-0.1±0.3；锌，-2.4±4.2；有抗坏血酸组：铁，-4.9±4.7；铜，0.1±0.6；锌，-2.7±3.1）。在低出生体重新生儿常规护理情况下给予的抗坏血酸补充剂，既不会增强铁的吸收和潴留，也不会损害铜和锌代谢的这些方面。