Duncan-Hewitt W C, Weatherly G C
Faculty of Pharmacy, University of Toronto, Ontario, Canada.
J Pharm Sci. 1990 Feb;79(2):147-52. doi: 10.1002/jps.2600790214.
A model is presented which uses the Vickers microindentation hardness of ductile crystals such as sodium chloride to predict the uniaxial compaction behavior of compacts. A general approach first developed in the materials science field to predict the densification of particulate matter under hydrostatic loading was followed. However, modifications to account for the effects of particle geometry and the closed-die loading conditions were considered. Using the standard microindentation hardness value of sodium chloride, the model predicted the densification behavior of this material at a punch displacement rate of 1 mm/min. Densification at higher compaction rates was predicted by considering the effect of deformation kinetics on the hardness. Secondary factors which affect compaction, such as particle size effects and die-wall friction, are also briefly discussed.
本文提出了一个模型，该模型利用诸如氯化钠等延性晶体的维氏显微硬度来预测压坯的单轴压实行为。遵循了材料科学领域最初开发的一种通用方法，以预测静水压力下颗粒物质的致密化。然而，考虑了对颗粒几何形状和封闭模具加载条件影响的修正。使用氯化钠的标准显微硬度值，该模型预测了该材料在冲头位移速率为1毫米/分钟时的致密化行为。通过考虑变形动力学对硬度的影响来预测更高压实速率下的致密化。还简要讨论了影响压实的次要因素，如颗粒尺寸效应和模壁摩擦。
