Industrial Pharmacy Research Group, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
Pharm Dev Technol. 2013 Feb;18(1):46-54. doi: 10.3109/10837450.2011.598163. Epub 2011 Aug 3.
Dwell time mainly depends on punch geometry, so some tableting problems such as capping and lamination could occur at high speed compaction. Robust tools are required to monitor the interaction of punch tip and powder bed at these high speeds. Our aim was to investigate the effect of punch geometry (flat and standard concave) on powder compaction at high speed using radial die-wall pressure (RDWP) as a monitoring tool. Instrumented die guided by compaction simulation was applied for five materials with different compaction behaviors. Flat-faced punch showed higher residual, maximum die-wall pressures, and axial stress transmission than concave punches, p < 0.003. Moreover, flat-faced punches showed less friction upon ejection, p < 0.003. Flat compacts showed higher elastic recovery, tensile strength, and required less work of compaction than convex compacts, p < 0.05. RDWP monitoring was a useful tool to prove that flat-faced punch induced higher radial stresses and particle/particle interactions in comparison to concave punch.
停留时间主要取决于冲头几何形状,因此在高速压缩时可能会出现一些片剂问题,如顶裂和分层。需要坚固的工具来监测这些高速下冲头尖端和粉末床之间的相互作用。我们的目的是使用径向模壁压力 (RDWP) 作为监测工具,研究冲头几何形状(平冲头和标准凹冲头)对高速粉末压缩的影响。使用具有不同压缩行为的五种材料对仪器化模具进行了压缩模拟引导。平冲头的残余、最大模壁压力和轴向应力传递比凹冲头高,p < 0.003。此外,平冲头在推出时的摩擦力更小,p < 0.003。平压块的弹性恢复率较高,拉伸强度较高,所需的压缩功比凸压块少,p < 0.05。RDWP 监测是一种有用的工具,可以证明与凹冲头相比,平冲头会在粉末中产生更高的径向应力和颗粒/颗粒相互作用。