Department of Paediatrics, St. John's Medical College and Hospital, Bangalore, India.
Pediatr Infect Dis J. 2013 May;32(5):e227-9. doi: 10.1097/INF.0b013e31827fb2d1.
Analysis of treatment response among HIV-infected children in India on first-line antiretroviral treatment for >2 years revealed that 85% were virologically suppressed. Of those with virologic failure, only 17% manifested immunologic failure, whereas majority had resistance-associated mutations. The presence of resistance highlights the need for virologic monitoring of children receiving antiretroviral treatment to optimize treatment success and preserve future treatment options.
对在印度接受一线抗逆转录病毒治疗超过 2 年的 HIV 感染儿童的治疗反应进行分析，结果显示，85%的患儿病毒学抑制。在病毒学失败的患儿中，仅有 17%表现出免疫失败，而大多数患儿存在耐药相关突变。耐药的存在突出表明，需要对接受抗逆转录病毒治疗的儿童进行病毒学监测，以优化治疗效果并保留未来的治疗选择。
