Department of Digestive and Endocrine Surgery, CCDE, IMAD, CHU Nantes, Nantes, France.
Langenbecks Arch Surg. 2013 Jun;398(5):729-33. doi: 10.1007/s00423-012-1040-7. Epub 2012 Dec 19.
The aim of this study was to assess the safety and efficacy of adrenalectomy on patients with pheochromocytoma diagnosed at the time of an acute heart failure (AHF).
We reported cases of patients who presented an AHF secondary to a pheochromocytoma during a period of 10 years. The diagnosis of AHF was defined by a left ventricular ejection fraction of less than 30 % or the use of circulatory assistance. They had adrenalectomy as emergency surgery or later. Morbidity and mortality of surgery were studied.
Thirteen patients required an adrenalectomy for AHF secondary to pheochromocytoma. Four patients (31 %) had an adrenalectomy in emergency. Nine patients (69 %) had a delayed surgery with a median delay of 25 days (7-180). Eight patients had circulatory assistance (61 %). Five of them had a circulatory assistance and a delayed surgery (38 %), two of them had a circulatory assistance followed by emergency surgery (at 1.5 and 3 days) and one had emergency surgery immediately followed by circulatory assistance. Emergency surgery was performed by laparotomy in all cases and delayed surgery by laparoscopy for seven patients (54 %). Perioperative complications consisted in: one circulatory arrest, two bleedings requiring transfusion, one intestinal ischaemia, one haemoperitoneum with re-operation (day 8). One patient died on day 5. Post-operative course of patients with delayed surgery was uneventful.
AHF revealing a pheochromocytoma is a rare and serious event. Patients with emergency surgery have more complications than those with delayed surgery.
本研究旨在评估在急性心力衰竭(AHF)时诊断为嗜铬细胞瘤患者行肾上腺切除术的安全性和疗效。
我们报告了 10 年间因嗜铬细胞瘤引起 AHF 的患者病例。AHF 的诊断定义为左心室射血分数小于 30%或使用循环辅助。这些患者行紧急手术或择期肾上腺切除术。研究了手术的发病率和死亡率。
13 例因嗜铬细胞瘤引起的 AHF 需要行肾上腺切除术。4 例(31%)行急诊手术。9 例(69%)行择期手术,中位延迟时间为 25 天(7-180 天)。8 例患者接受了循环辅助治疗(61%)。其中 5 例患者接受了循环辅助治疗和择期手术(38%),2 例患者接受了循环辅助治疗后行急诊手术(分别在第 1.5 天和第 3 天),1 例患者立即行急诊手术并随后接受了循环辅助治疗。所有病例均行剖腹手术行急诊手术,7 例(54%)行腹腔镜手术行择期手术。围手术期并发症包括:1 例循环骤停,2 例需要输血的出血,1 例肠缺血,1 例血腹需再次手术(第 8 天)。1 例患者于术后第 5 天死亡。择期手术患者的术后过程无并发症。
急性心力衰竭时发现嗜铬细胞瘤是一种罕见且严重的事件。行急诊手术的患者比行择期手术的患者并发症更多。