Salvi Vaibhav, Karnad Dilip R, Kerkar Vaibhav, Panicker Gopi Krishna, Manohar Deepak, Natekar Mili, Kothari Snehal, Narula Dhiraj, Lokhandwala Yash
Quintiles Cardiac Safety Services, Mumbai, India.
Indian Heart J. 2012 Nov-Dec;64(6):535-40. doi: 10.1016/j.ihj.2012.07.023. Epub 2012 Aug 1.
Conventionally, QT interval is measured in lead II. There are no data to select an alternative lead for QT measurement when it cannot be measured in Lead II for any reason.
We retrospectively analyzed ECGs from 1906 healthy volunteers from 41 phase I studies. QT interval was measured on the median beat in all 12 leads. The mean difference in QT interval between lead aVR and in Lead II was the least, followed by aVF, V5, V6 and V4; lead aVL had maximum difference. The T wave was flat (<0.1 mV) in Lead II in 6.9% of ECGs; it was also flat in 20% of these ECGs (1.4% of all ECGs) in Leads aVR, aVF and V5.
When QT interval cannot be measured in Lead II, the best alternative leads are aVR, aVF, V5, V6 and V4 in that sequence. It differs maximally from that in Lead II in Lead aVL.
传统上,QT间期是在II导联测量的。当由于任何原因无法在II导联测量QT间期时,尚无数据可用于选择替代导联进行QT测量。
我们回顾性分析了来自41项I期研究的1906名健康志愿者的心电图。在所有12个导联的中位心搏上测量QT间期。aVR导联与II导联之间QT间期的平均差异最小,其次是aVF、V5、V6和V4导联;aVL导联的差异最大。在6.9%的心电图中,II导联的T波平坦(<0.1mV);在这些心电图中,20%(占所有心电图的1.4%)的aVR、aVF和V5导联的T波也平坦。
当无法在II导联测量QT间期时,最佳的替代导联依次为aVR、aVF、V5、V6和V4导联。它与II导联的差异在aVL导联中最大。