男男性行为人群中正在发生的梅毒疫情的流行病学特征，旧金山。
Epidemiologic characteristics of an ongoing syphilis epidemic among men who have sex with men, San Francisco.
机构信息
San Francisco Department of Public Health, San Francisco, CA 94103, USA.
出版信息
Sex Transm Dis. 2013 Jan;40(1):11-7. doi: 10.1097/OLQ.0b013e31827763ea.
BACKGROUND
Since 2001, San Francisco has experienced a sustained syphilis epidemic that has been nearly exclusively limited to men who have sex with men. We examined the characteristics associated with changes in the syphilis epidemic in San Francisco.
METHODS
All primary and secondary (P&S) syphilis cases reported to the San Francisco Department of Public Health between 2001 and 2011 were examined using joinpoint analysis to identify periods within the broader epidemic. Characteristics of the index cases were compared across the periods using χ(2) statistics and t tests.
RESULTS
Three distinct periods were identified, an acute increase, decline, and then period of resurgence. In the most recent period of resurgence, compared with earlier periods, patients with P&S syphilis were more likely to have a prior syphilis infection, were older, were more likely to meet partners online, and were more likely to have a partner from outside San Francisco.
CONCLUSIONS
In an analysis of 11 years of P&S syphilis data, several factors were associated with declines or resurgences. Innovative prevention measures are needed to reduce syphilis morbidity among men who have sex with men.
背景
自 2001 年以来，旧金山经历了一场持续的梅毒疫情，几乎完全局限于男男性接触者。我们研究了与旧金山梅毒疫情变化相关的特征。
方法
使用 joinpoint 分析，对 2001 年至 2011 年期间向旧金山公共卫生部报告的所有原发性和继发性（P&S）梅毒病例进行了检查，以确定更广泛疫情中的各个时期。使用 χ(2)检验和 t 检验比较各时期的索引病例特征。
结果
确定了三个不同的时期，即急性增加、下降和再次出现。在最近的再次出现时期，与早期时期相比，P&S 梅毒患者更有可能先前感染过梅毒，年龄更大，更有可能在网上结识伴侣，并且更有可能伴侣来自旧金山以外的地方。
结论
在对 11 年原发性和继发性梅毒数据的分析中，有几个因素与下降或再次出现有关。需要采取创新的预防措施来降低男男性接触者的梅毒发病率。
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