Calabro A, Singletary S E, Carrasco C H, Legha S S
Department of General Surgery, University of Texas M.D. Anderson Cancer Center, Houston 77030.
J Surg Oncol. 1990 Apr;43(4):239-44. doi: 10.1002/jso.2930430410.
The therapeutic effectiveness of intraarterial cisplatin (CDDP) and dacarbazine (DTIC) infusion was examined in 30 evaluable patients with regionally advanced melanoma that was refractory to standard treatments. Objective responses were achieved in 11 patients (37%), including three complete (10%) and eight partial (27%) tumor regressions. Successful debulking surgery was performed in seven of the eleven patients with response. Six remained free of regional disease after a median time of 25 months, and four are also free of distant metastases at 24+, 25+, 41+, and 54+ months. Nineteen of thirty patients with no significant tumor response underwent alternative treatments. Debulking surgery was performed in nine, but with little palliative gain, since seven relapsed at a median time of 5 months. Our results suggest that a combined therapeutic approach--preoperative chemotherapy followed by surgery in responding tumors--represents an effective treatment for patients with regionally advanced melanoma.
对30例对标准治疗无效的局部晚期黑色素瘤患者进行了动脉内顺铂（CDDP）和达卡巴嗪（DTIC）灌注治疗的疗效研究。11例患者（37%）获得客观缓解，包括3例完全缓解（10%）和8例部分缓解（27%）。11例有反应的患者中有7例成功进行了减瘤手术。6例患者在中位时间25个月后无局部疾病复发，4例患者在24 +、25 +、41 +和54 +个月时也无远处转移。30例无明显肿瘤反应的患者中有19例接受了替代治疗。9例患者进行了减瘤手术，但姑息效果甚微，因为7例患者在中位时间5个月时复发。我们的结果表明，一种联合治疗方法——术前化疗，然后对有反应的肿瘤进行手术——对局部晚期黑色素瘤患者是一种有效的治疗方法。
