铜增强化合物：抗分枝杆菌药物发现的新概念。
Copper-boosting compounds: a novel concept for antimycobacterial drug discovery.
机构信息
Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
出版信息
Antimicrob Agents Chemother. 2013 Feb;57(2):1089-91. doi: 10.1128/AAC.01781-12. Epub 2012 Dec 17.
Abstract
We and others recently identified copper resistance as important for virulence of Mycobacterium tuberculosis. Here, we introduce a high-throughput screening assay for agents that induce a copper hypersensitivity phenotype in M. tuberculosis and demonstrate that such copper-boosting compounds are effective against replicating and nonreplicating M. tuberculosis strains.
摘要
我们和其他人最近发现铜抗性对结核分枝杆菌的毒力很重要。在这里，我们引入了一种高通量筛选检测试剂的方法，该试剂可在结核分枝杆菌中诱导铜超敏表型，并证明这种增强铜的化合物对复制和非复制的结核分枝杆菌菌株均有效。
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