Department of Immunobiology, University of Arizona College of Medicine - Tucson, Tucson, AZ 85724, USA.
Department of Immunobiology, University of Arizona College of Medicine - Tucson, Tucson, AZ 85724, USA; Valley Fever Center for Excellence, University of Arizona College of Medicine - Tucson, Tucson, AZ 85724, USA; BIO5 Institute, University of Arizona College of Medicine - Tucson, Tucson, AZ 85724, USA; Asthma and Airway Disease Research Center, University of Arizona College of Medicine - Tucson, Tucson, AZ 85724, USA.
Curr Opin Microbiol. 2023 Oct;75:102355. doi: 10.1016/j.mib.2023.102355. Epub 2023 Jul 3.
Antibiotic-resistant microbe-mediated deaths are a major worldwide health issue. Unfortunately, due to microbial adaptation to develop resistance, some antibiotics are nullified early in their usage, and worse, resistance is detected before they can even be prescribed. Copper's toxicity since antiquity against microbes at the host-pathogen interface offers a fascinating weapon to fight antimicrobial resistance. Here, we briefly review why copper is so effective, how drugs that work with copper are effective antimicrobials, and how compounds such as these could reinvigorate investment in antimicrobial development.
耐药微生物介导的死亡是一个全球性的主要健康问题。不幸的是，由于微生物适应产生耐药性，一些抗生素在使用早期就失效了，更糟糕的是，在这些抗生素被开出处方之前，就已经检测到了耐药性。自古以来，铜在宿主-病原体界面上对微生物的毒性为对抗抗微生物耐药性提供了一种引人入胜的武器。在这里，我们简要回顾一下为什么铜如此有效，以及与铜一起作用的药物如何成为有效的抗菌药物，以及这些化合物如何重新激发对抗微生物药物开发的投资。
