Synthesis of a North-methanocarba-thymidine (N-MCT) analog.
作者信息
Thompson Andrew, Marquez Victor E
机构信息
J-Star Research, Inc., South Plainfield, New Jersey, USA.
出版信息
Curr Protoc Nucleic Acid Chem. 2012 Dec;Chapter 1:Unit1.29. doi: 10.1002/0471142700.nc0129s51.
Abstract
A detailed protocol for the synthesis of North-methanocarba-thymidine (N-MCT), a potent antiviral nucleoside with a restricted bicyclo[3.1.0]hexane pseudosugar conformation, is presented. The process is described in two parts. The first basic protocol deals with the synthesis of the carbobicyclic pseudosugar precursor that can be utilized in the syntheses of other bicyclo[3.1.0]hexane nucleosides with natural and non-natural nucleobases. The second basic protocol describes the specific construction of the thymine base in a linear fashion from the carbobicyclic intermediate.
摘要
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