Malluche H H, Faugere M C
Department of Medicine, University of Kentucky Medical Center, Lexington 40536-0084.
Metabolism. 1990 Apr;39(4 Suppl 1):24-6. doi: 10.1016/0026-0495(90)90267-g.
Ovariohysterectomized Beagle dogs provide a useful model for the study of bone loss following cessation of ovarian function. Data obtained in our laboratory suggest that the sequence of events occurring after cessation of such function proceeds in two phases. The first, or "initiation," phase begins within 1 month after ovariohysterectomy (OHX). Although the number of osteoclasts is unchanged, there is an increase in trabecular separation, accompanied by a dramatic decrease in cancellous bone volume, which suggests an apparent dramatic hyperresorption. This early phase is followed by a "maintenance" phase, which commences in the second month and is related to an osteoblastic insufficiency. In another experiment, administration of 1,25(OH)2D3 corrected bone loss occurring after OHX in Beagle dogs. However, a positive balance between increased bone cell activity and decreased bone cell number was not maintained. This calls for new strategies to separate the positive effect of 1,25(OH)2D3 on bone cell activity from the negative effect on bone cell number.
卵巢子宫切除的比格犬为研究卵巢功能停止后的骨质流失提供了一个有用的模型。我们实验室获得的数据表明，卵巢功能停止后发生的一系列事件分两个阶段进行。第一个阶段，即“启动”阶段，在卵巢子宫切除（OHX）后1个月内开始。尽管破骨细胞数量没有变化，但小梁间距增加，同时松质骨体积急剧减少，这表明明显的过度吸收。这个早期阶段之后是“维持”阶段，该阶段从第二个月开始，与成骨细胞功能不全有关。在另一项实验中，给予1,25(OH)2D3可纠正比格犬OHX后发生的骨质流失。然而，骨细胞活性增加与骨细胞数量减少之间并未保持正平衡。这就需要新的策略来将1,25(OH)2D3对骨细胞活性的积极作用与对骨细胞数量的消极作用区分开来。
