出生时小于胎龄的矮小儿童的生长情况及其对生长激素治疗的反应。

Growth of short children born small for gestational age and their response to growth hormone therapy.

机构信息

Department of Endocrinology, Bharati Vidyapeeth University Medical College, and Growth and Pediatric Endocrine Unit, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India.

出版信息

Indian Pediatr. 2013 May 8;50(5):497-9. doi: 10.1007/s13312-013-0151-8. Epub 2012 Oct 5.

DOI:10.1007/s13312-013-0151-8

PMID:23255677

Abstract

Growth hormone [GH] is licensed for use in children born small for gestational age (SGA) who fail to catch-up. We retrospectively compared the response of twenty children born SGA (who satisfied the auxological criteria) to growth hormone (Group I) versus randomly selected age and sex matched controls from a group of SGA children with growth related complaints, not treated with GH (Group II). After 2 years of GH therapy the HAZ increased from -2.8 to -1.6 in Group I, compared 2.2 to -1.7 in group II (P-value < 0.05). The percentage of pubertal children rose from 55% to 65% in cases versus 60% to 75% in the controls (P>0.05). GH resulted in increase in growth velocity Z-score during the first year and (4.3±0.5 in Group-I versus - 0.5±0.6 in Group-II, P<0.05) second year of treatment (1.7±0.4 in cases versus -0.6±0.7 in controls, P<0.05).Thus, GH improves height of short SGA children without accelerating pubertal progression.

摘要

生长激素[GH]被批准用于未能追赶生长的胎龄小的出生体重儿（SGA）。我们回顾性比较了二十名满足生长学标准的 SGA 儿童（SGA 组 I）对生长激素的反应与一组有生长相关投诉、未用生长激素治疗的 SGA 儿童（SGA 组 II）中随机选择的年龄和性别匹配的对照。在 GH 治疗 2 年后，SGA 组 I 的 HAZ 从-2.8 增加到-1.6，而 SGA 组 II 则从 2.2 增加到-1.7（P 值<0.05）。青春期儿童的比例从 55%增加到 65%，而对照组则从 60%增加到 75%（P>0.05）。GH 导致第一年生长速度 Z 评分增加（SGA 组 I 为 4.3±0.5，而 SGA 组 II 为-0.5±0.6，P<0.05）和第二年治疗期间（SGA 组 I 为 1.7±0.4，而对照组为-0.6±0.7，P<0.05）。因此，GH 可改善矮小 SGA 儿童的身高，而不会加速青春期进展。